Monday, December 17, 2012

Source: Obama to nominate Kerry as secretary of state (CNN)

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Math formula gives new glimpse into the magical mind of Ramanujan

Dec. 17, 2012 ? December 22 marks the 125th anniversary of the birth of Srinivasa Ramanujan, an Indian mathematician renowned for somehow intuiting extraordinary numerical patterns and connections without the use of proofs or modern mathematical tools. A devout Hindu, Ramanujan said that his findings were divine, revealed to him in dreams by the goddess Namagiri.

"I wanted to do something special, in the spirit of Ramanujan, to mark the anniversary," says Emory mathematician Ken Ono. "It's fascinating to me to explore his writings and imagine how his brain may have worked. It's like being a mathematical anthropologist."

Ono, a number theorist whose work has previously uncovered hidden meanings in the notebooks of Ramanujan, set to work on the 125th-anniversary project with two colleagues and former students: Amanda Folsom, from Yale, and Rob Rhoades, from Stanford.

The result is a formula for mock modular forms that may prove useful to physicists who study black holes. The work, which Ono recently presented at the Ramanujan 125 conference at the University of Florida, also solves one of the greatest puzzles left behind by the enigmatic Indian genius.

While on his death-bed in 1920, Ramanujan wrote a letter to his mentor, English mathematician G. H. Hardy. The letter described several new functions that behaved differently from known theta functions, or modular forms, and yet closely mimicked them. Ramanujan conjectured that his mock modular forms corresponded to the ordinary modular forms earlier identified by Carl Jacobi, and that both would wind up with similar outputs for roots of 1.

No one at the time understood what Ramanujan was talking about. "It wasn't until 2002, through the work of Sander Zwegers, that we had a description of the functions that Ramanujan was writing about in 1920," Ono says.

Building on that description, Ono and his colleagues went a step further. They drew on modern mathematical tools that had not been developed before Ramanujan's death to prove that a mock modular form could be computed just as Ramanujan predicted. They found that while the outputs of a mock modular form shoot off into enormous numbers, the corresponding ordinary modular form expands at close to the same rate. So when you add up the two outputs or, in some cases, subtract them from one another, the result is a relatively small number, such as four, in the simplest case.

"We proved that Ramanujan was right," Ono says. "We found the formula explaining one of the visions that he believed came from his goddess."

Ono uses a "magic coin" analogy to illustrate the complexity of Ramanujan's vision. Imagine that Jacobi, who discovered the original modular forms, and Ramanujan are contemporaries and go shopping together. They each spend a coin in the same shop. Each of their coins goes on a different journey, traveling through different hands, shops and cities.

"For months, the paths of the two coins look chaotic, like they aren't doing anything in unison," Ono says. "But eventually Ramanujan's coin starts mocking, or trailing, Jacobi's coin. After a year, the two coins end up very near one another: In the same town, in the same shop, in the same cash register, about four inches apart."

Ramanujan experienced such extraordinary insights in an innocent way, simply appreciating the beauty of the math, without seeking practical applications for them.

"No one was talking about black holes back in the 1920s when Ramanujan first came up with mock modular forms, and yet, his work may unlock secrets about them," Ono says.

Expansion of modular forms is one of the fundamental tools for computing the entropy of a modular black hole. Some black holes, however, are not modular, but the new formula based on Ramanujan's vision may allow physicists to compute their entropy as though they were.

After coming up with the formula for computing a mock modular form, Ono wanted to put some icing on the cake for the 125th-anniversary celebration. He and Emory graduate students Michael Griffin and Larry Rolen revisited the paragraph in Ramanujan's last letter that gave a vague description for how he arrived at the functions. That one paragraph has inspired hundreds of papers by mathematicians, who have pondered its hidden meaning for eight decades.

"So much of what Ramanujan offers comes from mysterious words and strange formulas that seem to defy mathematical sense," Ono says. "Although we had a definition from 2002 for Ramanujan's functions, it was still unclear how it related to Ramanujan's awkward and imprecise definition."

Ono and his students finally saw the meaning behind the puzzling paragraph, and a way to link it to the modern definition. "We developed a theorem that shows that the bizarre methodology he used to construct his examples is correct," Ono says. "For the first time, we can prove that the exotic functions that Ramanujan conjured in his death-bed letter behave exactly as he said they would, in every case."

Although Ramanujan received little formal training in math, and died at the age of 32, he made major contributions to number theory and many other areas of math.

In the fall, Ono traveled to Ramanujan's birth home in Madras, and to other significant sites in the Indian mathematician's life, to participate in a docu-drama. Ono acted as a math consultant, and also has a speaking part in the film about Ramanujan, directed by Nandan Kudhyadi and set to premiere next year.

"I got to hold some of Ramanujan's original notebooks, and it felt like I was talking to him," Ono says. "The pages were yellow and falling apart, but they are filled with formulas and class invariants, amazing visions that are hard to describe, and no indication of how he came up with them."

Ono will spend much of December in India, taking overnight trains to Mysore, Bangalore, Chennai and New Dehli, as part of a group of distinguished mathematicians giving talks about Ramanujan in the lead-up to the anniversary date.

"Ramanujan is a hero in India so it's kind of like a math rock tour," Ono says, adding, "I'm his biggest fan. My professional life is inescapably intertwined with Ramanujan. Many of the mathematical objects that I think about so profoundly were anticipated by him. I'm so glad that he existed."

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The above story is reprinted from materials provided by Emory University. The original article was written by Carol Clark.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/0mLTtGAZgfg/121217091604.htm

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Palestinian premier: Boycott Israeli goods

RAMALLAH, West Bank (AP) ? The Palestinian premier called on his people Sunday to boycott Israeli products, the latest step in an economic battle between Palestinians and Israelis spurred by the Palestinians' status upgrade last month at the United Nations.

Palestinian Prime Minister Salaam Fayyad, a U.S.-educated economist, told reporters the call for a boycott is a protest against Israel's withholding of funds to the cash-strapped Palestinian Authority.

Israel is holding $100 million in taxes it collects on behalf of the Palestinians, based on an interim peace accord. It cut off the funds to protest the Palestinians' successful bid last month at the United Nations, which granted the Palestinians non-state observer status. Israel said the Palestinian move was an attempt to bypass peace negotiations. Palestinians deny that.

Israel has briefly withheld tax transfers on previous occasions to pressure the Palestinians.

The Palestinian Authority government in the West Bank uses the money to pay salaries to its tens of thousands of civil servants and security forces. Israel said it is using the money to pay down huge debts Fayyad's government owes to Israeli firms, including its electricity company.

Fayyad admitted a Palestinian boycott of Israeli goods would violate an interim peace agreement with Israel, in which the two sides pledged economic cooperation, but he justified the move because "the Israeli government is working against this agreement" by withholding tax funds.

Israeli Foreign Ministry spokesman Yigal Palmor said the Palestinians should "concentrate efforts on how to build their own economy, not how to boycott someone else's."

In the past, Fayyad called for a boycott of goods made in Israeli settlements, but that boycott appears to have had no impact. Palestinians oppose settlements because they are located on West Bank land they claim for a future state.

This is the first time Fayyad has called for a boycott of all Israeli goods, not just ones made in West Bank settlements. Such a boycott would severely limit goods on the Palestinian market, as Palestinians are heavily dependent on Israel for consumer products.

To recoup its losses from the Israeli fund cutoff, the Palestinians have turned to Arab countries to donate funds.

"We are trying to prevent the collapse of the Palestinian Authority," Fayyad said.

Source: http://news.yahoo.com/palestinian-premier-boycott-israeli-goods-170151942--finance.html

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Monday, December 10, 2012

Italian parties begin campaigning, cajole Monti

ROME (Reuters) - Italy's political parties began maneuvering on Sunday ahead of elections expected in February as supporters of technocrat Prime Minister Mario Monti sought to cajole him to stay in politics.

Monti has repeatedly said he would not campaign for power, but that he would be willing to serve again as an apolitical premier should the vote result be unclear.

But the premier's unexpected resignation in the face of People of Freedom (PDL) leader Silvio Berlusconi's attacks against his stewardship of the economy are fuelling speculation that Monti is ready to join the race.

Italian "progressives" from the centre-left's Democratic Party (PD) to the Union of the Centre (UDC) "identify with the reasonable and responsible policies Monti has made," UDC leader Pier Ferdinando Casini said on Sunday.

"A large part of civil society does not want to return to the populism and demagoguery of the past. We must give them the political offering they seek."

PD front-runner candidate Pier Luigi Bersani lauded Monti's plan to resign immediately after the passage of the budget, saying it showed great dignity. Bersani won a U.S.-style primary vote last week in which he promised to continue down the path taken by the premier.

The PD leads the PDL by at least 16 percentage points, according to polls from last week.

Berlusconi's campaign against European Union-inspired austerity that was put in place to stem the spread of a debt crisis "risks undermining the painful sacrifices that each Italian has made this year to save the national economy," PD lower house president Dario Franceschini said.

Italians are indeed burdened by the recession, which began mid-way through last year and shows no signs of abating. Many blame Monti's tax increases for making it worse. Unemployment is at a record high and consumer spending has collapsed.

"Eggs and potatoes, eggs and potatoes, that's all we can afford to eat right now," said Roberta Uzzo, who lives near the ancient walls of Rome. "It's a very ugly period. My husband is unable to find any work and with one sole income it's very difficult to go forward."

PDL secretary Angelino Alfano, whose attacks in parliament on Friday Monti said prompted him to step down, defended his party's decision to withdraw its support for the government.

"We think we did the right thing" in declaring Monti's government over on Thursday, Alfano said, "to underscore the struggles that Italians are facing because of the dire economic situation."

The consummate showman Berlusconi bashed Monti's leadership as he declared his sixth bid for power on the soccer pitch of his AC Milan team on Saturday, but Monti stole the scene by resigning later in the day and counter-attacking that "populism" was only a shortcut to winning votes.

MARKETS

Early elections in Italy must not hinder Monti's economic reforms, European Commission President Jose Manuel Barroso warned in an interview with financial daily Il Sole 24 Ore.

"The next elections must not serve as a pretext for putting in doubt how indispensable these measures are," he said in Sunday's edition. "The relative calm on the markets does not mean we are out of the crisis."

Berlusconi's withdrawal of support for the government last week triggered a new rise in 10-year bond yields, the main barometer of market opinion, reversing weeks of steady falls.

The yield on the 10-year BTP stood at 4.5 percent at the end of last week, 323 basis points higher than the yield on lower risk German 10-year Bunds, but much lower than the level of 7.3 percent seen last year.

Much will depend on how investors view the prospect of a potentially messy election campaign and a likely government of the centre-left, led by a former communist.

"From the perspective of international investors, it is worth noting that so far, I have heard nothing from the Bersani camp that would make me worry about Italian reforms or Italy's newly reclaimed place at the table among other leading European or G-7 members," Unicredit global chief economist Erik Nielsen wrote in a note.

Former European Commissioner Monti came to power at the height of the financial crisis a year ago and was widely credited with restoring Italy's credibility with investors and European partners after the scandal-plagued Berlusconi era.

"Whoever governs Italy, a founding member of the EU, is going to have to pursue this course with the same seriousness," European Central Bank executive board member Joerg Asmussen said on Sunday in Germany's Bild newspaper.

Berlusconi's centre-right PDL lags the PD by as much as 20 percentage points in opinion polls, and also trails the anti-establishment 5-Star Movement, which has surged to prominence on a tide of public anger against the mainstream political class.

Italy's four small centrist blocs would draw less than 10 percent of the vote if elections were held today, polls show.

(Additional reporting by James Mackenzie and Hanna; Rantala in Rome and Lisa Jucca in Milan; Editing by Barry Moody and Stephen Powell)

Source: http://news.yahoo.com/italian-parties-begin-campaigning-cajole-monti-153437304--business.html

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Sunday, December 9, 2012

K-State holds off George Washington 65-62

? In Kansas State?s first true road game of the season at George Washington, the Wildcats clanked early and often in the first half, ended shooting less than 36 percent for the game. Fortunately, they also grabbed 24 offensive rebounds and combined with Angel Rodriquez?s second half scoring fueled a 65-62 victory.

"I?ll tell you one thing," K-State coach Bruce Weber said after the Wildcats improved to 7-1. "I?d love to make some shots so we haven?t so many offensive (rebounding) opportunities. Hopefully, that will come as it goes, but we got to continue to use that as a strength."

Another strength for the Wildcats was Rodriquez?s consistent second-half penetration. Following a dismal start ? he missed seven of eight field goal attempts ? the sophomore guard scored 14 of his 17 points in the second half, including five inside the final 1:46.

Playing in front of around 60 friends and family, D.C. native Rodney McGruder finished with 15 points and 11 rebounds.

K-State also played inside a raucous Smith Center as the Colonials (4-5) hosted their first BCS program since the 2009-10 season. Last season the Wildcats hosted and defeated George Washington 69-56. The Colonials play in the Atlantic 10.

After the Wildcats trailed by as many as seven before halftime, they led 44-37 following a 15-4 run early in the second half. The Colonials bounded back with a 13-4 run, going ahead 50-48 on Dwayne Smith?s 3-point play with 9:03 remaining, setting up the back-and-forth finish.

"As a coach you know that you?re walking into a tough environment," Weber said. "I?m not sure the kids understood it. To our guys credit, they hung in there we survived the first half, had a great run to start the second half and then even survived another run by then."

They survived shooting 31.6 percent in the first half by working the offensive glass; K-State?s first three baskets of the game all came on putbacks by Nino Williams.

McGruder scored 12 before halftime.

"It?s just great, having the opportunity to play in front of a lot family and friends and to do right in the heart of Washington, D.C.," McGruder said. "I couldn?t ask for a better opportunity."

For the game, the Wildcats finished at 35.7 percent (25 of 70), but held a 46-36 rebounding advantage with Thomas Gipson grabbing 12.

Isaiah Armwood had 12 points, 10 rebounds and a havoc-causing seven blocks for the Colonials while Smith had 14 points.

"I thought our defense was terrific," George Washington coach Mike Lonergan said. "If you told me we?re going to hold them to 35 percent shooting I thought we could win the game. But the killer was the 24 offensive rebounds."

Rodriquez?s second half prowess also destroyed the Colonials.

Williams? putback with 3:18 remaining put the Wildcats ahead for good. On their next possession ? which included another offensive rebound ? Rodriguez generated points by shrewdly taking advantage of his previous driving forays. With K-State leading 58-57, he wound up being fouled while attempting a 3-pointer then knocked down all three free throws with 1:46 left.

"Shot clock was going down and I felt like (the defender) was expecting me to drive cause I was driving constantly," Rodriquez said. "I was fortunate to get to the free throw line and make my free throws."

After Armwood made 3 of 4 free throws, Rodriguez sought out another driving opportunity. With his defender assuming the same, Rodriquez pulled up for a right-wing jumper with 1:03 left that pushed the lead back to 63-60.

"Angel made some huge plays when we needed it," Weber said

Source: http://www.kansas.com/2012/12/08/2596865/k-state-holds-off-george-washington.html

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  • "Dell storage boss Topgun Thomas leaves 'to pursue a new opportunity': Darren Thomas, head of Dell's Storage Group, is leaving the company, following several quarters of declining revenue and an influx of new executive blood into Dell."?The Register?12:23 PM
  • "AMD Cuts Chip Orders From Globalfoundries Amid PC Slump"?Bloomberg?9:24 AM
  • "AMD slashes chip orders as PC market slumps: The company has reduced orders to contract chip maker GlobalFoundries in the current quarter from $500 million down to $115 million"?IDG News Service?10:56 AM
  • "Intel upping Atom ante"?EE Times?10:23 AM
  • "Intel releases open source GraphBuilder for big data"?V3?12:28 PM
  • "Intel says it remains committed to user-replaceable CPUs for 'foreseeable future'"?ZDNet?12:44 PM
  • "Cisco's Chambers Affirms Revenue Target Amid Expansion"?Bloomberg?9:26 AM
  • "Cisco's Chambers: Here's How We've Outgunned Our Competitors"?CRN?10:11 AM
  • "Cisco's mid-term growth strategy betting on IT software, security"?ZDNet?12:43 PM
  • "Cisco bets on software and services for mid-term growth"?Reuters?1:06 PM
  • "Cisco CEO sees tech services driving steady growth"?MarketWatch?1:04 PM
  • "Cisco to 'Bring Sex' to Marketing Campaign"?TheStreet?12:59 PM
  • "FAA urged to allow portable devices during takeoff"?TG Daily?12:08 PM
  • "The UN's Internet power grab: An FAQ/What it is, what it isn't, and how it will affect you."?PCWorld?11:27 AM
  • "Silicon Valley Needs To Get Out More: The next great technology problems to solve are out there in rail yards, power plants and farm fields. If Silicon Valley is going to drive this 'Internet of things,' it needs to build closer ties with companies in established industries."?InformationWeek?9:53 AM
  • "The grinch who stole IT's Christmas: Bad news about IT wages and bonuses, as well as job pressures from offshoring and shift to the cloud, dampen holiday cheer"?InfoWorld?10:54 AM
  • "Why the desktop PC may see a comeback in the mobile era"?InfoWorld?10:54 AM
? ?

Source: http://www.macsurfer.com/redirr.php?u=745924

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Saturday, December 8, 2012

Gun turns up in package of frozen ribs at NM store

ROSWELL, N.M. (AP) ? New Mexico authorities say they're puzzled by what turned up in a package of meat at a Roswell grocery store.

A worker at Albertsons opened a case of frozen ribs Wednesday and found a handgun and ammunition packed with the meat.

Roswell police Sgt. Jim Preston tells Albuquerque television station KRQE (http://bit.ly/XwlNQB ) that it would be speculation to say how it got there.

Authorities have some clues.

A police report shows that the meat came from the Swift Packing Plant in Greeley, Colo., and is marked with the date June 8, 2011.

Greeley police say they're reviewing cases to see if the gun was used in any crimes.

Authorities say the semi-automatic Rock Island Armory .38 Super had not been reported stolen. A firearms trace could take weeks.

___

Information from: KRQE-TV, http://www.krqe.com

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2012-12-07-Pistol%20in%20Meat/id-556ddac8e652488484d74bcc4f7137c5

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Waiting for dialogue with India: IOC

JAIPUR: On Tuesday, the IOC executive board took an extreme step by suspending the Indian Olympic Association. The IOC made it clear that any activities of the IOA will not be recognized by the world body. However, the IOA went ahead with its elections on the next day.

In an exclusive interview with TOI, Pere Miro, director of NOC relations at the IOC, says that the body was forced to take such a decision after repeated warnings to set the house in order fell on deaf ears. Excerpts:

IOA has gone ahead and held elections. Apart from not recognizing the new committee, can the IOC penalize the IOA further?

The IOC does not recognize any such election and that is the end of the matter. As far as the IOC is concerned, Mr VK Malhotra was the functional president when the IOA was suspended and Mr Randhir Singh was the general secretary. We continue to recognize that and any further changes in the IOA don't really affect us.

Now that the IOA has been suspended, what is the stand vis-a-vis India's representative to IOC, Randhir Singh?

I'd like to make it clear that the action is against the IOA and not individuals. Mr Randhir Singh continues to hold his posts in the Olympic Association Of Asia and the IOC.

Has the Indian govt or the IOA approached the IOC after the suspension?

Since the suspension, nobody from India has approached us. We are open to dialogue. If anyone from India does approach us, we are ready to hold talks to sort out the issue. The IOC is keen to ensure that sporting activities happen in India smoothly.

What happens to Indian athletes participating in international events?

India cannot participate in any event held under the IOC jurisdiction as a nation as long as the suspension remains in force. That would include events like the Olympics and the Asian Games. When it comes to athletes, the issue will be dealt with on a case-by-case basis. However, in single sport, for example Asian Table Tennis Championship which is conducted by the ITTF, the IOC will respect the decision of the governing body of that sport.

What happens to the Olympic quota places up for grabs in these events?

Quota places for future games are an issue for us. The Olympic Games is still far away and we do hope the issue with the IOA is resolved by then. As of now, if any Indian earns a quota place, the IOC won't really take any decision on that. However, if the issue is not resolved by the time of the Olympics, the IOC would have to take some decision. As of now, the IOC will just wait.

The Indian govt says it only wants to ensure fair elections at IOA in accordance to the Olympic Charter. Your reactions.

If the Indian government says it is not interfering with the IOA election, we would welcome the idea and we would want to understand the details. If they say that they are following the Olympic Charter, they should show it. The Olympic Charter ensures harmony among the IOC, the 204 National Olympic Committees and the laws of all the countries. Normally, we would deal with the IOA only. But then, in this case, we are open to discussions with the Indian government. We are waiting to have dialogue with anyone interested in doing so.

The Indian judiciary wanted IOA elections as per the Sports Code. How could the IOA defy the Court?

We respect the decisions of justice in every nation. But then, the judges will deliver their verdict as per the laws of the nation. The concerned nation should look at the laws regarding sport and ensure that the sports organizations remain autonomous and in harmony with the principles of the Olympic Charter.

Source: http://timesofindia.feedsportal.com/fy/8at2Etd0ha35N3fE/story01.htm

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DoorBot lets you see and talk with who's at the door from the comfort of your smartphone (video)

DoorBot lets you see and talk with who's at the door from the comfort of your smartphone video

If funding is successful, you'll be able to wave hello to Edison Junior's DoorBot -- an app-enabled, WiFi-connected video doorbell. Sure, it's not exactly the first time we've seen such an idea, but the "weather-resistant," aluminium enclosure makes it one of the best looking concepts we've seen. Better yet, the system is set to work in unison with the Lockitron (a smartphone-controlled keyless door lock that was recently crowd-funded, albeit still yet to ship) allowing you to let welcome visitors inside your abode at the tap of your iOS or Android Device's app screen.

The DoorBot installs with four screws, but it'll have you running through four AA batteries once a year for power (which, based on the video, seem easily removeable by strangers, unfortunately). There's no word on the quality of the camera onboard, however, it's infared-equipped, so you'll be able to see who's there at night. Lastly, the actual doorbell button is wrapped with an LED light, and, as you'd expect, it alerts you via the app when pressed to see and speak with whomever is at the door.

In total, Edison Junior hopes to raise a lofty $250,000 to make the DoorBot more than a concept video, with 45 days to reach the goal. If you're willing to take the gamble as backer, $169 is what'll cost to secure a pre-order, and $319 snags you one bundled with the Lockitron. We're told that we'll see a working prototype in the flesh at CES, but until then, you can catch the full sales pitch at the source link and video demo after the break.

Continue reading DoorBot lets you see and talk with who's at the door from the comfort of your smartphone (video)

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Source: Edison Junior (Christie Street)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Z7xrhvDuxZ8/

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Friday, December 7, 2012

Gene network illuminates stress, mutation and adaptation responses

ScienceDaily (Dec. 6, 2012) ? For much of her professional life, Dr. Susan Rosenberg has studied the puzzling response of bacteria to stress and the mutations that result. In the current issue of the journal Science, she puts together the pieces of that puzzle, describing most of the members of an elaborate gene network that functions in causing mutations during repair of double-stranded breaks in the DNA of stressed cells.

"We now know the 93 genes more than half of which are funneling into three nodes that go down the mutagenesis pathway," said Rosenberg, professor of molecular and human genetics at Baylor College of Medicine and 2009 winner of the National Institutes of Health Director's Pioneer Award.

Groundbreaking work

Rosenberg's groundbreaking work has shown that the rate of mutation can be increased in response to stress such as starvation or environmental challenges such as antibiotics. This changes old ideas about constant and gradual accumulation of mutations over time. Some mutations are detrimental; others can promote survival. In this work, she and her colleagues sought to define the cellular pathways that result in this stress response.

"We screened for every gene in Escherichia coli that is needed to make this happen," said Rosenberg. E. coli is a "model" organism often used in the laboratory to study cells, because its DNA and other components work similarly to those in humans.

They have found that the mutagenic part of the process is not required to repair the broken DNA strands. When they "knock out" or remove the special "error-prone" DNA copying enzyme or polymerase, "the DNA is repaired beautifully and there are no mutations." So, cells do not make mutations because they have to, to repair DNA. Rather, this mechanism appears to regulate production of mutations, making more during stress, when cells are poorly adapted to their environments, and most likely to benefit from mutations.

Painstaking process

"Fewer than 16 proteins that are needed to accomplish stress-inducible mutagenesis were known previously. This is about the number known for any molecular mechanism of DNA biology," said Rosenberg. "Our screen sought the whole list of all proteins the cell uses to make it happen."

The painstaking process, begun by then postdoctoral fellow Dr. Mary-Jane Lombardo, now of Seres Health, Inc., in Cambridge, Mass., was completed by Dr. Amar Al Mamun, an assistant professor in Rosenberg's laboratory at BCM.

Large fractions of the network work "upstream" of the activation of the stress response, showing that these proteins apparently "sense" the stress. In delineating how the network functions, Rosenberg and her colleagues identified specific pathways through which the proteins sense the environment and connected them to the molecular mechanism that promotes the mutations.

Key factors revealed

The findings reveal key factors about the cells, such as that stress-response regulators act as key network hubs, she said. Most of the proteins in the network deal with whether or not the cells feel stress, said Rosenberg.

"The cell devotes a large number of proteins to controlling the process that generates diversity," she said. "And most of them are sensing the environment and coupling mutagenesis to stress."

They have determined the function of about half the network and are working on the rest.

"It's a resounding confirmation of the regulation of mutagenesis by stress responses, which causes mutations specifically when cells are maladapted to their environment when mutations might allow the cell to adapt," said Rosenberg.

Protein networks

It is also a demonstration that one can hope to detangle large protein networks into specific biological functions. Large protein networks are being discovered in many areas of biology, but what roles the proteins play in particular biological processes is often difficult to determine. Rosenberg's study shows that by working backwards from a defined molecular mechanism, they could assign roles to more than half the network proteins. Rosenberg thinks this strategy will be useful for many other protein networks.

Funding for this work came from grants from the National Institutes of Health and National Science Foundation.

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The above story is reprinted from materials provided by Baylor College of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Abu Amar M. Al Mamun, Mary-Jane Lombardo, Chandan Shee, Andreas M. Lisewski, Caleb Gonzalez, Dongxu Lin, Ralf B. Nehring, Claude Saint-Ruf, Janet L. Gibson, Ryan L. Frisch, Olivier Lichtarge, P. J. Hastings, Susan M. Rosenberg. Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks. Science, 7 December 2012: Vol. 338 no. 6112 pp. 1344-1348 DOI: 10.1126/science.1226683

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/fK3OEfGMG4g/121206142014.htm

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T-Mobile and Apple sign agreement to launch products in 2013

TMobile and Apple sign agreement to launch products in 2013

Dreams can come true, folks: T-Mobile and Apple have entered an agreement and will be launching products beginning next year. The announcement was posted (nearly as an afterthought, oddly enough) as part of a press release in which Deutsche Telekom spelled out its financial plans through 2015, while COO Rene Obermann also made the announcement in an investors conference. While the two companies have not explicitly given specifics on which Apple devices we can expect to see in a retail store near you, the timing of the launch will likely correspond with the fourth-largest carrier's LTE launch in 2013.

We've reached out to T-Mobile and Apple for comment and will update this post as we hear more. For now, check out the press release in all its glory below.

Developing..

Continue reading T-Mobile and Apple sign agreement to launch products in 2013

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Via: Sascha Segan (Twitter)

Source: Deutsche Telekom (Twitter), Deutsche Telekom

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ywonCmcd6EQ/

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Charlotte Daily Deals 12/7/12: Jake?s Good Eats, Bonterra, golf lessons, BOSS archery, Buddy Valastro Live!, more

$25 for $50 Worth of Contemporary American Cuisine and Nonalcoholic Drinks at Bonterra Dining & Wine Room

A raw steak can reduce the swelling of a black eye just as easily as the charcoal markings of a well-cooked steak can draw it back on. Make artful use of cuisine with this Groupon.

$25 for $50 Worth of Contemporary American Cuisine and Nonalcoholic Drinks

Starters such as Prince Edward Island mussels ($13) introduce a fire-roasted Angus beef filet mignon ($37) or a 12-ounce fried lobster tail with sweet-and-sour mustard aioli ($39). See the full menu here.

Groupon Says

The Groupon Guide to: Dog-Show Breed Standards

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Southern-Style Dinner or Lunch at Jake???s Good Eats (Half Off)

Dining out gives you a break from cooking and keeps your crippling fear of fire a secret for one more night. Get a hot meal with this Groupon.

Choose Between Two Options

  • $20 for $40 worth of Southern-style food for dinner, served 5 p.m.?9 p.m. Tuesday?Saturday
  • $10 for $20 worth of Southern-style food for lunch, served 11 a.m.?9 p.m. Tuesday?Thursday and 11 a.m.?2:30 p.m. Friday and Saturday

At dinner, the kitchen dishes out hearty Southern-style entrees, such as crawfish-sauce-smothered flounder over country-ham grit cakes ($16), crawfish and North Carolina shrimp ?touff?e ($10), and grilled salmon painted with a honey-mustard-and-molasses glaze with asparagus and mushroom risotto ($18). Sandwiches, such as oyster po? boys ($7) and pit-smoked barbecue topped with carolina slaw ($6), round off lunch options. See the full menu.

Jake's Good Eats is closed Sunday and Monday.

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$29 for One Complete Teeth-Whitening Session at Pro White Teeth Whitening ($129 Value)

Keeping teeth clean and white is the first and only step in coping with the fact that your skeleton is slowly escaping from your body through your mouth. Deal with it with this Groupon.

$29 for One Complete Teeth-Whitening Session ($129 Value)

During each 20-minute complete teeth-whitening session, a qualified technician aids you in applying Beaming White's FDA-approved, light-activated peroxide gel to teeth. Clients then grin at a gentle blue-spectrum LED lamp, which makes the gel molecules break through enamel?s defensive line and bleach away stains. The highly effective treatment immediately renders smiles up to 10 shades whiter. Results last 6?12 months. Individual results and time between treatments may vary and will be discussed prior to treatment.

Groupon Says

The Groupon Guide to: Impromptu Holiday Games

Should December be called Game-cember?

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One- or Two-Night Stay for Two with Appetizer at Clarion Inn & Suites Greenville in Greenville, SC

Top Reasons to Stay at Clarion Inn & Suites Greenville

  • The hotel is a 10-minute drive from downtown Greenville, where you can find restaurants, entertainment, and the Greenville Zoo. The zoo?s newest additions are a pair of Schmidt's spot-nosed guenons, making it one of only 10 North American zoos to have these rare African monkeys.
  • Haywood Mall is within walking distance and contains more than 150 shops, including Macy?s, Gap, and the Apple Store.
  • The free deluxe hot breakfast buffet spread includes cereal, hot dishes, and make-your-own waffles.
  • Each guest room has a refrigerator, microwave, and 32-inch plasma TV with cable.
  • The hotel is near the foothills of the Blue Ridge Mountains, where you can hike, bike, and golf.

Read the Fine Print for important info on travel dates and other restrictions.

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Dry-Cleaning for a Comforter or $12 for $25 Worth of Dry-Cleaning Services at Holiday Dry Cleaners

Some clothes aren?t meant to get wet, much like some robots, and all wicked witches of the west. Keep your delicates from melting with this Groupon.

Choose Between Two Options

  • $24 for dry-cleaning for a comforter (a $49.99 value)
  • $12 for $25 worth of dry-cleaning services

Services include dry-cleaning for pants ($6.49), blouses ($6.49), rain coats ($15.99), and golf shirts ($3.99).

Groupon Says

The Groupon Guide to: DVD Commentary Reveals

What behind-the-scenes movie secrets did we learn from director?s commentaries?

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$12 for $25 Worth of Ultra-Thin Wallets from Big Skinny

Like a flock of geese, a wallet is filled with bills and should instinctually return home every spring after flying south to spend your money. Adopt a new pocket pet with this Groupon.

$12 for $25 Worth of Men?s and Women?s Ultra-Thin Wallets

Big Skinny wallets keep cards and cash safe in 1 of 36 sleek designs for both men and women, a holiday gift for unorganized pockets. The multi-pocket bifold ($23.95) packs away up to 25 plastic cards in pockets lined with rubber backing that prevents them from being lost when held upside down. Containing four extra-wide pockets, the trifold wallet ($24.95) closes snugly around credit cards and snapshots, and red, leather passport holders ($23.95+) keep couples sleek while jetting to romantic destinations or romantically breaking into the Kremlin. Big Skinny also bestows ultra-thin technology on money clips ($19.95), cell-phone wallets ($25.95), clutches ($29.95), checkbook covers ($13.95), and card holders ($7.95).

Groupon Says

The Groupon Guide to: Dog-Show Breed Standards

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One or Three 60-Minute Foot-Reflexology Treatments at Stonehaven Massage & Spa (Up to 55% Off)

Like a recharged cell phone, a recharged body is less likely to shut down midconversation. Charge your bodily battery with this Groupon.

Choose Between Two Options

  • $35 for one 60-minute foot-reflexology treatment (a $70 value)
  • $95 for three 60-minute foot-reflexology treatments (a $210 value)

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Groupon Says

The Groupon Guide to: Dog-Show Breed Standards

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50-Minute Signature or Men's Facial, or a 80-Minute Pure Gold Facial at Eden Skin and Body Institute (Up to 54% Off)

Human beings instinctively put their own likenesses everywhere: pumpkins, mountainsides, and text messages to Kevin. Illuminate the original emoticon with this Groupon.

Choose Between Two Options

  • $45 for a 50-minute signature facial or 50-minute men's facial (a $90 value)
  • $65 for an 80-minute Pure Gold facial (a $140 value)

The custom signature facial restores skin with cleansing, exfoliation, and an ampoule infusion, whereas the men's facial soothes and hydrates skin suffering from razor irritation. Alternatively, the Pure Gold facial infuses the skin with collagen for increased firmness, elasticity, and radiance.

Groupon Says

The Groupon Guide to: Dog-Show Breed Standards

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Haircut and Style with Optional All-Over Color or Full Highlights at Alter Image Salon & Spa (Up to 57% Off)

Unlike a chameleon, hair does not naturally change color or fight you when you try to put a satin bow on it before taking its picture. Blend in or stand out with this Groupon.

Choose from Three Options

  • $15 for a haircut and style (a $30 value)
  • $35 for a haircut and style with all-over color (a $45 value; a $75 total value)
  • $65 for a haircut and style with full two-dimensional highlights and lowlights (a $120 value; a $150 total value)

Groupon Says

The Groupon Guide to: Dog-Show Breed Standards

Is that dog really a dog?

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Eight-Lap Racing Experience or Three-Lap Ride-Along from Rusty Wallace Racing Experience (Half Off)

After a few laps around a racetrack, humans don?t need coffee to feel awake, and cars don't need a splash of burnt-rubber-scented cologne to get ready for dates. Feel an adrenaline rush with this Groupon.

Choose Between Two Options

  • $199 for a two-hour, eight-lap Qualifier racing experience (a $399 value)
  • $64 for a one-hour, three-lap shotgun ride-along experience (a $129 value)

Experiences are currently scheduled for the following weekend dates:

  • March 15?16
  • April 19?20
  • May 31
  • June 1
  • July 19?20
  • August 30?31
  • November 8?9

Rusty Wallace Racing Experience engages adrenal glands with real-life rubber-burning packages that send speed demons around Charlotte Motor Speedway's D-shaped oval track. With the shotgun ride-along, need-for-speeders can hop into the passenger seat of a stock car and share three laps? worth of in-the-action views with a professional driver.

The Qualifier racing experience condenses the pro-racing experience into two hours of intense zooming. After classroom instruction familiarizes soon-to-be drivers with the course?s corners, students get to take the wheel for eight invigorating laps, leaving their hair mussed, their eyes bulging, and their torsos coated in corporate sponsorships.

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Airport Shuttle Service for One, Two, or Four Within the 485 Loop from EcoSeat (Up to 60% Off)

Having a driver chauffeur you to the airport takes the edge off of standing in security lines and watching the TSA officers try on your slacks. Travel in style with this Groupon.

Choose from Three Options

  • $18 for one-way shuttle service for one passenger (up to a $45 value)
  • $23 for one-way shuttle service for two passengers (up to a $55 value)
  • $28 for one-way shuttle service for four passengers (up to a $60 value)

Shuttle service is available to or from Douglas Charlotte International Airport for passengers within the 485/Harris Boulevard loop. Customers can request a shuttle schedule here. Pets are allowed on board, as long as they are in a carrying case and nobody booked for the trip has allergies. Shuttles are not handicapped accessible.

Customers are encouraged to arrange their shuttle service as soon as travel dates have been scheduled.

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$39 for a Sprinkler Winterization Package for Up to Six Zones from The EarthScape Company ($85 Value)

Lush grass makes a yard more beautiful, unlike weeds or a statue of Benjamin Franklin inventing spandex. Protect your yard's good side with this Groupon.

$39 for Sprinkler-System Winterization ($85 Value)

Skilled technicians cover and protect six sprinkler zones from the harsh winter elements.

Groupon Says

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Face to Face ??? Tribute to Billy Joel & Elton John at The Fillmore Charlotte on Friday, January 11, at 9 p.m.

Concerts give music lovers the chance to gather together to hear their favorite artist and share one giant, meaty party sub. Share a moment with this GrouponLive deal to see Face to Face ? Tribute to Billy Joel & Elton John at The Fillmore Charlotte. For $7, you get one G-Pass for general-admission on Friday, January 11, at 9 p.m. (up to a $13 value, including all fees). Doors open at 8 p.m. Because the ticket is a G-Pass, Groupon customers can use it to enter the venue directly; they will not need to redeem their Groupon at will call.

Sitting on opposite ends of the stage at their respective pianos, the dual impersonators of Face to Face ? Tribute to Billy Joel & Elton John conjure the beloved songsters in both sound and image. Joey Riedel dons the iconic purple sunglasses and bedazzled suits of Elton John as he charts his style from the ?70s to the present. Bittersweet anthems such as "Rocket Man (I Think It's Going to Be a Long, Long Time)" mix with more whimsical material such as "Crocodile Rock" and the fictional rock-group narrative "Bennie and the Jets." Backed by a full band, Michael John's fingers flash up and down the piano before he jumps up to grab the mic to belt out such high-energy Billy Joel classics as "Uptown Girl" and "Only the Good Die Young." The pair interacts with each other and the audience with bits of spontaneous humor and sing-alongs, culminating in a "Face to Face" finale in which they trade piano licks, swap shoes, and intertwine lyrics for a show-stopping finish.

The Fillmore Charlotte

Housing the explosion of fast-paced rock, The Fillmore Charlotte models itself on the iconic San Francisco venue. Once a textile mill, the open space follows the original Fillmore?s signature decor, from red-oak hardwood floors to glimmering chandeliers to stadium-style tiers that result in pristine sightlines for attending fans.

Due to security restrictions, G-Passes must be printed out and presented in person at the event. They cannot be redeemed through Groupon's mobile app.

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$37 for a One-Hour Private Golf Lesson from Dave Bayko - PGA Professional ($75 Value)

Golf is so beloved because it combines two of humankind's favorite things?hitting stuff and driving on someone else's lawn. Play through with this Groupon.

$37 for a One-Hour Private Golf Lesson ($75 Value)

During the private lesson, PGA pro Dave Bayko works with individuals to reinforce fundamental swing aspects such as grip, stance, posture, and alignment.

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Women's or Coed Two-Hour Standup-Paddleboard Class for One or Evening Class for Two from Local Paddler (Up to 61% Off)

Biologists estimate that water makes up 65% of the human body, 71% of the planet's surface, and 0% of the R&B group Earth, Wind & Fire. Conquer the planet?s most prevalent liquid with this Groupon.

Choose from Three Options

  • $39 for a two-hour women's standup-paddleboard course for one (a $99 value)
  • $45 for a two-hour standup-paddleboard course for one (a $99 value)
  • $90 for a romantic two-hour evening standup-paddleboard course for two (a $198 value)

From May through September?weather and water conditions permitting?Groupon holders follow along as a guide teaches standup-paddleboard basics and water-safety skills before turning paddlers loose on waterways including Tailrace Marina, Lake Norman, Lake Wylie, Mountain Island Lake, and the Catawba River. Evening cruises gain a romantic edge over their diurnal counterparts as the sun?s dip toward the horizon coincides with the bullfrog jazz band?s rehearsals. On weekends, daytime tours run from 10 a.m. to noon and 1 p.m. to 3 p.m., and evening tours run from 4 p.m. to 6 p.m. All gear is provided.

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$99 for a Three-Hour Afternoon Fishing Trip on Lake Norman from Fishin' With Capt. Gus ($200 Value)

Fish are an elusive prey, fleeing into reefs to evade anglers and spontaneously sprouting legs to run away from Charles Darwin. Track down slippery targets with this Groupon.

$99 for Three-Hour Afternoon Fishing Trip for One ($200 Value)

The afternoon fishing trip sets out onto the blue waters of Lake Norman for a three-hour expedition to reel in fish such as largemouth bass, catfish, and perch.

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$35 for an Archery Lesson with Gear and Range Time for Two at BOSS Archery Shop ($80 Value)

After Cupid popularized archery, hordes of people took it up to get back at him for meddling in their love lives. Fight arrows with arrows with this Groupon.

$35 for Archery Lesson for Two ($80 Value)

  • 30 minutes of professional instruction (a $20 value each)
  • 60 minutes of range time (a $10 value each)
  • Rental equipment (a $10 value each)

The Beginning Archery Course sets students down the path of the Archery Learning Academy?s Championship Learning Program. Developed by BOSS Archery Shop founder Clyde Hartsell, the program caters to archers looking to sharpen their skills for recreational, sporting, or competitive bow use.

Groupon Says

The Groupon Guide to: Tricking Your Kids into Eating Vegetables

Mom, can I have seconds of goblin teeth?

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Contemporary Handcrafted Furniture, Lighting, and Home Decor with Free Shipping from Infurn (Up to 51% Off)

Customized furniture is designed to be personal, whether it is a table built to fit a room?s exact specifications or a sofa embroidered with the owner?s diary entries. Find distinct home decor with this Groupon.

Choose Between Two Options

  • $99 for $200 worth of contemporary handcrafted furniture, lighting, and home decor
  • $149 for $300 worth of contemporary handcrafted furniture, lighting, and home decor

Denmark-based Infurn purveys handcrafted pieces tailored exactly to each shopper?s wishes. Customers can peruse the slate of armchairs, sofas, tables, and lamps online, selecting pieces such as a flowerpot pendant lamp ($129), a bright-red ripple chair ($189), a BigBoy BeanBag XXL ($199), or an Aurica magazine stand ($299). Shipping is free; items may take up to 12 weeks to ship.

Groupon Says

The Groupon Guide to: Tricking Your Kids into Eating Vegetables

Mom, can I have seconds of goblin teeth?

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Four or Eight Buckets of Range Balls or One or Four Private Golf Lessons at The Effortless Golf Center (Up to 65% Off)

Ben Hogan called the pitching wedge the equalizer for its ability to rescue players from difficult lies and because he used it to enforce democracy. Add character to your clubs with this Groupon.

Choose from Four Options

  • $15 for four large buckets of driving-range balls (a $36 value)
  • $25 for eight large buckets of driving-range balls (a $72 value)
  • $29 for one private 45-minute golf lesson with PGA pro Bruce Parker (a $60 value)
  • $79 for four private 45-minute golf lessons with PGA pro Bruce Parker (a $180 value)

Groupon Says

The Groupon Guide to: Tricking Your Kids into Eating Vegetables

Mom, can I have seconds of goblin teeth?

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Framed Art, Prints, and Canvases from Art.com (Half Off). Two Options Available.

Without walls, art aficionados would have to sate their passion for aesthetic composition with real-life lily ponds, starlit caf?s, and gooeylicious candy pocket watches. Keep sticky scenes at a safe distance with this Groupon.

Choose Between Two Options

  • $25 for $50 worth of framed art, prints, and canvases
  • $50 for $100 worth of framed art, prints, and canvases

Full color saturates the Casablanca movie poster print ($37.99 for a 23.5"x31.5" print; $144.99 with added 1.25" wood frame) and Picasso's Grand Profil, 1963 ($44.99 for a 27.5?x27.5? print with border), shades of white dominate the selection of black and white photographs ($2.98 and up), and primary colors pop in Roy Lichtenstein?s In the Car, c. 1963 ($55.99 for a 27.5?x27.5? print; $194.99 with added 1.25? wood frame). This Groupon can be used toward any item from Art.com except for gift cards.

Groupon Says

The Groupon Guide to: Tricking Your Kids into Eating Vegetables

Mom, can I have seconds of goblin teeth?

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40, 70, or 100 Custom Flat Holiday Cards from Picaboo (Up to 61% Off)

Holiday cards can embody the feelings of the season, expressing the goodwill felt at Christmas or the shame felt at repurposing a card into a last-minute Halloween mask. Express yourself with this Groupon.

Choose from Three Options

  • $19 for 40 flat custom holiday cards on standard paper (a $39.60 value)?
  • $29 for 70 flat custom holiday cards on standard paper (a $69.30 value)?
  • $39 for 100 flat custom holiday cards on standard paper (a $99 value)

Free shipping is included for the quantities listed.

Spread seasonal cheer to loved ones with personalized holiday cards made with Picaboo's easy-to-use website. There are more than 260 designs and a customizable interface that allows you to tailor professional-looking cards. Simply upload family photos from your computer and scribe your own well wishes. Printed with high-quality, full-bleed color, cards can be further customized with photos and captions. Click here to view available card options

Groupon Says

The Groupon Guide to: Baby-Shower Gifts

You?re never too young to sleep on a futon.

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Cookie Bouquets from Corso???s Cookies (Up to 63% Off). Two Options Available.

The aroma of homemade cookies awakens other sense memories, from the warmth of a wood-burning stove to the sight of Grandma milking a cow above the mixing bowl. Hearken back to simpler times with this Groupon.

Choose Between Two Options

  • $15 for $40 worth of cookie bouquets
  • $25 for $65 worth of cookie bouquets

Send edible sentiments with a Birthday Surprise bouquet ($39.99), the Season's Greetings cookie bouquet ($39.99), a Santa Claus-themed bouquet ($39.99), or a Get Back on Your Feet cookie bouquet ($39.99), each outfitted with seven decorated cookies.

Groupon Says

The Groupon Guide to: Escaping a Glass Prison Cell

When is your town getting a glass prison?

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$99 for 12 Laser Hair-Loss Therapy at Legacy Hair Center ($708 Value)

Like losing your wallet, losing your hair robs you of your identity, and may yield a surprising number of credit-card charges for fur-lined tricorn hats. Recover lost strands with this Groupon.

$99 for 12 Laser Hair-Loss Therapy Treatments ($708 Value)

Legacy Hair Center sets its laser-powered sights on thin, overprocessed hair, using laser hair-therapy treatments to thicken strands and improve overall head health. As clients relax, a trained technician targets noggin tops with beams of concentrated cold light that painlessly penetrate the scalp's surface for 15?30 minutes at a time. Aside from aiming to stop the progression of hair loss, the treatments are also designed to improve the condition of common scalp disorders, such as psoriasis or chronic side ponytails. Although some patients notice results within the first 6 weeks, others note changes between 6 and 12 weeks or after 12 weeks.

Groupon Says

The Groupon Guide to: DVD Commentary Reveals

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60- or 90-Minute Custom Full-Body Massage at Steele Creek Physical Therapy & Balance Center (Up to 53% Off)

Massage therapy is among the best ways to achieve relaxation, on par with listening to actor Ed Harris chant in whale song. Sink into serenity with this Groupon.

Choose Between Two Options

  • $35 for a 60-minute custom full-body massage (a $70 value)
  • $45 for a 90-minute custom full-body massage (a $95 value)

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The Groupon Guide to: DVD Commentary Reveals

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$10 for $20 Worth of Pizza or Sandwiches at Sub Corral Sandwich Shop

If you only eat at restaurants, you won't have to keep food in the fridge and you'll have more room for the snowman you're not ready to say goodbye to. Keep your kitchen empty and your heart full with this Groupon.

Choose Between Two Options

  • $10 for $20 worth of pizza
  • $10 for $20 worth of club and sub sandwiches

The shop's staff can create small ($9+), medium ($10.25+) and large ($13+) pizzas with traditional or white sauce. Diners choose from toppings such as sausage, jalape?os, fresh garlic, and meatballs, or request their pizza by the slice ($2+) or in calzone form ($7.25+).

They also assemble submarine sandwiches ($4.45?$8.70) as well as club sandwiches such as the 9-Iron, piled with steak, mushrooms, onions, peppers, and melted cheese ($7.10). The Driver sports bacon, lettuce, tomatoes, and melted cheese ($6.40).

Groupon Says

The Groupon Guide to: DVD Commentary Reveals

What behind-the-scenes movie secrets did we learn from director?s commentaries?

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Buddy Valastro Live! Homemade for the Holidays Tour at Ovens Auditorium on December 12 at 7:30 p.m. (Up to $60.65 Value)

Studies have shown that watching a baking demonstration makes people 40% hungrier, 10% thirstier, and 1,200% more likely to enter the chef-hat industry. Don your apron and head for the kitchen with this GrouponLive deal to see the Buddy Valastro Live! Homemade for the Holidays Tour, with the star of TLC's Cake Boss, at Ovens Auditorium. For $33, you get one ticket for seating in the orchestra or rows AA?EE of the mezzanine on Wednesday, December 12, at 7:30 p.m. (up to a $60.65 value, including all fees). Doors open at 6:30 p.m.

On his family-friendly tour of live shows, TLC's celebrity chef Buddy Valastro shares the humorous, endearing stories and baking techniques that earned his apron the embroidered title of Cake Boss. A fourth-generation baker from Hoboken, New Jersey, Buddy?s career began at Carlo's Bake Shop (also known as Carlo's Bakery), which has been in his family for 102 years. From this humble mom-and-pop shop, Buddy?s confections, signature rolling pins, and piping bags became wildly popular, and grew to colonize an empire of multimedia enterprises, showing up on TV screens and book covers. In the course of his journey, he has whipped up decorative techniques that take cake architecture to new culinary and artistic heights. Throughout his live show of baking demonstrations, the acclaimed pastry chef muses on his everyday dealings with suppliers, deliveries, walk-in customers, and bridezillas who demand strapless frosting dresses. During his holiday shows, he spreads the joy of the holiday season by hauling onstage several members of the audience for impromptu cupcake and decorating sessions. Spectators can whet appetites in the venerable Ovens Auditorium, which sports seating for more than 2,000 guests and a storied history stretching back to 1955.?

Groupon Says

The Groupon Guide to: Escaping a Glass Prison Cell

When is your town getting a glass prison?

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$10 for $50 to Spend on Custom iPhone Cases and Gifts at Vistaprint ($50 Value)

Putting your personal touch on a holiday gift goes beyond choosing the perfect wrapping paper. Customize what's in the box with this deal from Vistaprint: ? $10 for $50 to spend on custom iPhone cases, stationery, personalized gifts, and more ? Find something for everyone, from photo mugs and calendars to monogrammed stationery ? Choose from 3,000 holiday card designs for your family, pick out party invitations, or nab gift labels ? Vistaprint has more than 15 years of experience creating unique, high-quality products

$10 for Personalized Elf Package from Santa at OriginalSantaLetter ($20 Value)

You've made your lists, you've checked them twice, and the results are finally in: Your child has been very good this year. Santa may not be making his rounds for a few more weeks, but you can speed up the sleigh ride with this deal from OriginalSantaLetter.com. Pay $10, and wrap up a customized Elf Package from St. Nick's workshop including a personal letter from the man in red, a certificate authenticating your kid's spot on the Nice List, and a special wish list that'll whisk any holiday hankerings straight to Santa's desk (a $20 value). Get your holly, jolly Christmas started well before the stockings get hung by the chimney with care, and your child will be grinning from ear to ear.

$50 for $150 to Spend on Vacation Packages by Marriott at Vacations by Marriott ($150 Value)

This season, treat yourself or a fellow travel junkie to a luxurious locale. With this deal from Vacations by Marriott, you'll pay $50 for $150 to spend on vacation packages, good for use on air-inclusive (hotel and flight) or land-only (hotel and car) combinations. From a Hawaiian getaway at Wailea Beach Marriott Resort & Spa in sunny Maui to a Costa Rica adventure at the Los Suenos Marriott Ocean & Golf Resort, you're sure to find the perfect destination from Marriott's extensive collection.

$15 for $30 to Spend on Star Wars-Licensed Merchandise at SuperHeroDen.com ($30 Value)

Like any good sci-fi enthusiast, you want a trusty droid to have your back -- or at least look good on it. Pay $15 for $30 to spend on Star Wars-licensed merchandise and strike back at the fashion empire with an array of franchise-favorite gear at SuperHeroDen.com. From T-shirts featuring Luke Skywalker and plush backpack buddies in the form of characters like R2D2 and Darth Vader to collectibles that include faux light sabers and Chewbacca bobble heads, this deal delivers a fan-centered experience with noticeable force. Want more? Check out SuperHeroDen.com on Facebook.

$35 for Family Photo Package at Sears Portrait Studio ($194 Value)

Pining for some professional shots of your family tree? Make a date with Sears Portrait Studio, and snap up a portrait package just in time for the holidays for $35 (a $194 value) that includes four portrait sheets, two wall portraits, and free sitting fees for up to 10 people. ? A highly trained photographer will help you select a background and pose ? Hassle-free photo sessions take 15 to 30 minutes -- perfect for little ones ? Four mix-and-match portrait sheets with the poses and sizes of your choice ? Two 10"x10" specialty wall portraits to display your smiling faces or give as gifts ? Make an appointment at one of hundreds of convenient locations

$38 for Stuffed Animal Package at Stuffies? ($90 Value)

Super-big, super-soft, and with super-secret pockets, Stuffies? remind your child that it's what's inside that counts. With this deal from Stuffies?, you'll pay $38 (regularly $90) for a holiday gift package, complete with a Stuffie?, a matching figurine, and an 11-volume adventure book series, with included shipping. Perfect for storing toys and trinkets, Stuffies? are supersized companions that keep your tyke's most treasured possessions safe. From Dash the horse to Sky the giraffe, you can choose from 11 snuggly friends and enjoy the complete book collection filled with stories promoting positive values, as well as a set of complimentary stickers. Winner of The National Parenting Center's 2012 Seal of Approval and the Parents' Choice Award, Stuffies? are the perfect gift for cuddling and cultivating character.

$36 for Custom Xbox Controller at MS4R Modz ($73 Value)

The gamer in your life is a serious competitor -- with the high scores to prove it. This holiday season, score some points of your own with this gift from MS4R Modz: Pay $36 (regularly $73) for a custom Xbox controller. You'll start with a standard controller before selecting one colorful shell and one set of custom buttons. Available in eye-catching hues that range from green apple to chrome pink, shells easily snap on and off without interfering with functionality, so your gaming wizard can continue to climb the scoreboard with a one-of-a-kind controller.

$29 for Personalized Canvas Print with Photo Retouching at Canvas People ($97 Value)

Whenever you see a photo of a delectable double-chocolate cake or a portrait of a precious puppy, you wish you could bring it to life. Transfer your most sentimental memories to the third dimension with this deal from Canvas People: For $29 (regularly $97) nab a 16" x 20" canvas print with photo retouching. First, choose an image that speaks to you -- or peruse the stock library for a vast selection of vibrant shots. Then, select an optional black, white, or gold frame and an enhancing effect, like pop-art for a retro flair or black and white for a classic touch. Canvas People will touch up your image, and seven to ten days later, a gallery-wrapped canvas that's finished with an eco-friendly protective coating will arrive at your doorstep, ready to breathe new life into your abode with art that truly stands out.

$20 for Digital Subscription for Pre-K to Second Grade at World Book Encyclopedia ($50 Value)

Get your child excited about reading something other than a gift tag with a digital subscription to World Book Kids and Early World of Learning by World Book Encyclopedia for $20 (a $50 value). Children as young as preschool-age will learn to love nonfiction with kid-friendly narrated stories, interactive games, and original videos, all developed by early childhood experts to teach major themes like numbers, shapes, and opposites. Strengthen early reading skills with phonics, vocabulary, and comprehension-building material, plus a visually enticing online encyclopedia. Students in kindergarten through second grade can dig into thousands of age-level-appropriate articles, intriguing images, and even sound clips to bring text to life.

$7 for One-Year Subscription at The Bark ($15 Value)

If your beagle's been bothering you for some pooch-related reading, Schnauzer Golden opportunityFetch a one-year subscription (five issues) to this mag catering to all things canine, from nutritious toppings for basic kibble to pup-friendly travel tipsEach issue includes stories from acclaimed authors, dog photography, advice from behaviorists, and moreMagazine with 15 years of experience offers an impressive pedigree Want more? Check out The Bark's website.

$10 for 20-Page Hardcover Photo Book at MyPublisher ($36 Value)

Your fam will flip when you gift a permanent display of your holly, jolly smiles. Pay $10 ($36 value) for a personalized 20-page, 8.75" x 11.25" classic hardcover photo book with your choice of a photo finish or book jacket cover from MyPublisher. Or, pay $19 ($90 value) and receive a personalized, 20-page, 11.5" x 15" deluxe hardcover photo book with super gloss pages. Download the quick, intuitive, and free software, select your images, and choose from more than 200 layouts; then add captions or pages of text. You can also customize the front and back covers for a very merry masterpiece.

$9 for iPhone/iPad Stand at Stand It ($20 Value)

Treat your touch screen devotee to a gift that'll keep their tablet or phone from falling flat. With this deal from Aduro, you'll snag the Stand it iPhone/iPad Stand for $9 (regularly $20). Also compatible with other tablets and smartphones, it's perfect for propping up those devices for use at home or on the go. Holds any phone or tablet with up to a ten-inch screenWorks both horizontally and verticallyWatch movies, compose emails, or use as a clock dockRubberized for maximum gripComes in five colors: classic black, pink, red, blue, or purpleShipping is included within the continental US

$15 for $30 to Spend on Gourmet Dipped Berries and Sweets at Shari's Berries ($30 Value)

Find out what happens when fresh berries and melted chocolate meet under the mistletoe with this deal from Shari's Berries. ? Pay $15 to spend on $30 worth of gourmet-dipped berries and treats ? Gift an assortment of plump, juicy strawberries dipped and decorated with holiday-themed designs ? Indulge in handmade holiday cake pops or Oreo and marshmallow chocolate-covered snowman hats ? Delight with Mrs. Fields cookies, fruit baskets, nuts, popcorn, and more

$12 for One iPhone and iPod Armband at LiveItNexus ($25 Value)

On your daily runs, you've been getting faster -- at picking up your iPod after dropping it, that is. Swap slippery paws for a secure sleeve with this deal from LiveItNexus: Pay $12 (regularly $25) for the iPhone and iPod armband, including free shipping to the US and Canada. Made of lightweight, flexible material that fits comfortably around your bicep, this armband also sports strong Velcro to keep it in place. Change albums and tracks, or answer a phone call, while staying on the move -- the pocket portion of this armband will ensure your iPhone or iPod is secure and protected. LiveItNexus is known for providing advanced technology solutions for daily needs, which, in this case, means keeping your tunes safe -- so you can save those sweaty palms for patting yourself on the back for a jog well done.

$10 for One Audio Book of Your Choice at Audiobooks.com ($20 Value)

The best gift of all this season doesn't have to come in a box. Turn the page on tradition and give the gift of a good read anywhere in North America with this deal from Audiobooks.com. ? $10 ($20 value) for one audio book of your choice ? Enjoy instantly on your iPhone or iPad (iOS 4 or higher), Android smartphone (version 2.3 or higher), laptop, or tablet ? Extensive library is organized by genre and includes more than 20,000 best-sellers ? Practical bookmarking feature makes it easy to pick up where you left off, even if you switch devices

$10 for $20 to Spend on Calendars at Calendars.com ($20 Value)

When their advent calendars reach the big day, make sure a practical present with a personal touch is waiting under the tree. Usher in 2013 with this deal from Calendars.com: ? $10 for $20 to spend on calendars, gifts, games, books, puzzles, and more ? Vast and varied selection of calendars in nearly 20 categories from art to travel ? Use the Gift Finder to shop by gender, age, and interests ? Personalize a photo calendar or pick out the perfect wall or desk calendar ? Founded in 1999, this company has an A+ BBB rating

$5 for Magazine Subscription at Parenting, Kiwi, National Geographic Kids and Little Kids ($8 Value)

Inspire kids with fun adventures -- or give parents peace of mind -- when you gift them one of these family-focused magazines: ? $8 ($15 value) for a one-year, 6-issue subscription to National Geographic Little Kids Fuel preschoolers' imaginations with animal stories, photos and games. ? $10 ($15 value) for a one-year, 10-issue subscription to National Geographic Kids Designed for curious minds ages 6 to 14, this adventurous mag makes learning fun. ? $5 ($8 value) a two-year, 22-issue subscription to Parenting Mod moms and dads can get guidance, tips, and tricks tailored for kids ages 0 to 5 ? $6 ($12 value) for a one-year, 6-issue subscription to Kiwi Build healthy habits for your brood, from nutritious recipes and eco-crafts to the latest health news.

$15 for $30 to Spend on Men's Underwear and More at 2(X)IST ($30 Value)

What will your man be wearing under his Santa suit this holiday season? For the naughty and nice on your list, give the gift of better-fitting, top-quality underwear, swimwear, apparel, accessories, and more with this deal from 2(X)IST: ? $15 for $30 worth of products that fit men's lives ? Stuff your guy's stocking with multipacks of briefs, boxer briefs, tees, socks, and more ? Find basics like 100% Pima cotton boxer briefs, or snag vivid colors and playful waistbands ? High-quality fabrics, contoured shapes, superior comfort, and unmistakably cool style

$5 for 1-Year Magazine Subscription at FamilyFun, Ranger Rick, and Scholastic Parent & Child ($12 Value)

Parents love to show off their proudest accomplishments -- their kids -- and with this deal, you can show off your gift-giving skills, too: ? $5 ($12 value) for a one-year, 10-issue subscription to FamilyFun Find fun activities, crafts, recipes, and ways to connect with your kids. ? $10 ($20 value) for a one-year subscription to Ranger Rick Connect kids ages 7 to 12 with animals and nature with amazing photography, stories, and activities, with no advertising to distract from the fun. ? $10 ($20 value) for a one-year subscription to Ranger Rick, Jr. Explorers ages 3 to 7 will appreciate 36 picture-book pages, activities, and educational content, with no advertising to distract from the fun. ? $4 ($10 value) for a one-year, 9-issue subscription to Scholastic Parent & Child Delve into advice on raising your children and balancing your own development, too.

$20 for Name Your Own Star at International Star Registry ($65 Value)

Catch the twinkle in their eyes as they look to the skies with this deal from the International Star Registry: Give the gift of a personalized star for $20 (a $65 value). Lucky recipients can join the ranks of celebrities, dignitaries, and even royalty who have their own celestial sparklers. Each star comes with a 16" x 12" full-color parchment certificate, personalized with the star's name, date, and coordinatesCreate a cluster of stars for the whole family in the same constellation, or make personalized corporate gifts Identification is easy with a custom 16" x 12" sky chart that features the star's name, date, constellation, and location circled in red A booklet on astronomy written by a professional astronomer includes additional sky chartsCelebrate the moment with a letter of congratulations/memorial for the recipient The new star name will be published in book form for registration in the US Copyright Office

$10 for $20 to Spend on Fragrances at FragranceShop.com ($20 Value)

Savor the sweet smell of holiday shopping success when you pay $10 for $20 to spend on perfume, cologne, and more from FragranceShop.com. ? Browse more than 7,000 brand-name fragrances ? Authentic finds from brands like Marc Jacobs, Burberry, Givenchy, and Ralph Lauren ? Shop by price range, brand, or popular items ? Score beautifully packaged gift sets for men and women ? Stock up on bath and body products

$20 for Mini Christmas Tree with Decorating Kit at ProPlants.com ($39 Value)

$20 ($39 value) for a live 18- to 22-inch European cypress tree in a holiday candy cane tin with decorating kitSpread holiday cheer with this fragrant, mini Christmas tree, which arrives ready to decorate in a festive red-and-white-striped candy cane tinAdorn your tree with 12 mini ornaments and a colorful set of plug-in mini electric lightsMakes a lovely tabletop or floor display in small spacesPlants ship directly from the growers to your door for best-quality results For more info, visit ProPlants.com and its Facebook page.

$120 for One-Year The Magic School Bus Science Membership at The Young Scientists Club ($240 Value)

If you want to drive your child to a future in science or engineering, buckle up and take this deal from The Young Scientists Club for a spin: Pay $120 for a one-year membership to The Magic School Bus Science Club (a $240 value). You can create a printable gift card and wrap this up as a holiday gift, too. You'll get a lot of mileage out of this investment -- each month for 12 months, members of the club receive a new science experiment kit delivered right to their doors; an e-newsletter, access to an online clubhouse, and a certificate of completion. Designed for children ages 5 to 12 years old, these kits provide fun, hands-on activities to get young scientists thinking and learning about scientific topics like magnets, light, volcanoes, bacteria and fungi, the human body, and more. Developed by a team of Ivy League educators and featuring relatable characters from the acclaimed series The Magic School Bus, these kits really pull out all the stops. Want more? Visit The Young Scientists Club on Facebook.

$15 for Box of The Favorite? Royal Riviera? Pears at Harry & David ($30 Value)

Food plays a starring role in your holiday traditions, and today, it takes center stage as your new favorite gift to give. With this deal from Harry & David, pay $15 (regularly $30) for one five-pound box of The Favorite? Royal Riviera? Pears, famed for their delicate, smooth flavor. Savor seven to twelve impeccable, handpicked pears "so big and juicy, you eat them with a spoon." These luscious fruits are expertly grown in orchards in southern Oregon, carefully harvested at maturity, chilled to reach their full sweetness potential, and feature a gold foil-wrapped pear for a regal presentation. Give thanks, show appreciation for a party host, delight a coworker, or shower friends and family with one of life's sweetest pleasures: a perfect bite.

$99 for 12 Assorted Bottles of Premium Wine at Windsor Vineyards ($216 Value)

What better way to celebrate the 12 days of Christmas than with 12 bottles of wine? Give your true love this deal from Windsor Vineyards: ? $99 ($216 value) for an assortment of 12 bottles of premium wine ? Perfect to bring to parties, give as hostess gifts, or pair with holiday meals ? Seven reds, from spicy and deep to light-bodied and fruity 2009 Windsor Vineyards Merlot (1), 2009 or 2011 Cosentino Winery Zinfandel (2), 2011 Stoneyfly Syrah (2), 2011 Windsor Vineyards Fusion Red (2) ? Five whites, from refreshing and tangy to mild and creamy 2011 Hopskotch Chardonnay (2), 2011 Windsor Vineyards Sauvignon Blanc (1), 2011 Windsor Vineyards Pinot Grigio (2) ? Windsor Vineyards is among the top three award-winning wineries in the US for more than 50 years

$15 for $30 to Spend on Custom Gifts at PersonalizationMall.com ($30 Value)

Just like the ornaments on a Christmas tree, every person is different. Celebrate the uniqueness of friends and family with this deal from PersonalizationMall.com: $15 for $30 to spend on personalized holiday gifts and d?cor to match. Create your own photo ornaments, customize a holiday doormat for relatives, and shop for stocking stuffers like personalized santa hats or mugs. You can use cutting-edge preview technology to see what the present will look like, but you can rest assured it'll be impressive: This shop is a six-time winner of Bizrate's Circle of Excellence award and boasts an A-plus rating from the Better Business Bureau.

Source: http://www.charlotteonthecheap.com/2012/12/charlotte-daily-deals-12712-jakes-good-eats-bonterra-golf-lessons-boss-archery-buddy-valastro-live-more/

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