Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/271036439?client_source=feed&format=rss
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Dec. 17, 2012 ? December 22 marks the 125th anniversary of the birth of Srinivasa Ramanujan, an Indian mathematician renowned for somehow intuiting extraordinary numerical patterns and connections without the use of proofs or modern mathematical tools. A devout Hindu, Ramanujan said that his findings were divine, revealed to him in dreams by the goddess Namagiri.
"I wanted to do something special, in the spirit of Ramanujan, to mark the anniversary," says Emory mathematician Ken Ono. "It's fascinating to me to explore his writings and imagine how his brain may have worked. It's like being a mathematical anthropologist."
Ono, a number theorist whose work has previously uncovered hidden meanings in the notebooks of Ramanujan, set to work on the 125th-anniversary project with two colleagues and former students: Amanda Folsom, from Yale, and Rob Rhoades, from Stanford.
The result is a formula for mock modular forms that may prove useful to physicists who study black holes. The work, which Ono recently presented at the Ramanujan 125 conference at the University of Florida, also solves one of the greatest puzzles left behind by the enigmatic Indian genius.
While on his death-bed in 1920, Ramanujan wrote a letter to his mentor, English mathematician G. H. Hardy. The letter described several new functions that behaved differently from known theta functions, or modular forms, and yet closely mimicked them. Ramanujan conjectured that his mock modular forms corresponded to the ordinary modular forms earlier identified by Carl Jacobi, and that both would wind up with similar outputs for roots of 1.
No one at the time understood what Ramanujan was talking about. "It wasn't until 2002, through the work of Sander Zwegers, that we had a description of the functions that Ramanujan was writing about in 1920," Ono says.
Building on that description, Ono and his colleagues went a step further. They drew on modern mathematical tools that had not been developed before Ramanujan's death to prove that a mock modular form could be computed just as Ramanujan predicted. They found that while the outputs of a mock modular form shoot off into enormous numbers, the corresponding ordinary modular form expands at close to the same rate. So when you add up the two outputs or, in some cases, subtract them from one another, the result is a relatively small number, such as four, in the simplest case.
"We proved that Ramanujan was right," Ono says. "We found the formula explaining one of the visions that he believed came from his goddess."
Ono uses a "magic coin" analogy to illustrate the complexity of Ramanujan's vision. Imagine that Jacobi, who discovered the original modular forms, and Ramanujan are contemporaries and go shopping together. They each spend a coin in the same shop. Each of their coins goes on a different journey, traveling through different hands, shops and cities.
"For months, the paths of the two coins look chaotic, like they aren't doing anything in unison," Ono says. "But eventually Ramanujan's coin starts mocking, or trailing, Jacobi's coin. After a year, the two coins end up very near one another: In the same town, in the same shop, in the same cash register, about four inches apart."
Ramanujan experienced such extraordinary insights in an innocent way, simply appreciating the beauty of the math, without seeking practical applications for them.
"No one was talking about black holes back in the 1920s when Ramanujan first came up with mock modular forms, and yet, his work may unlock secrets about them," Ono says.
Expansion of modular forms is one of the fundamental tools for computing the entropy of a modular black hole. Some black holes, however, are not modular, but the new formula based on Ramanujan's vision may allow physicists to compute their entropy as though they were.
After coming up with the formula for computing a mock modular form, Ono wanted to put some icing on the cake for the 125th-anniversary celebration. He and Emory graduate students Michael Griffin and Larry Rolen revisited the paragraph in Ramanujan's last letter that gave a vague description for how he arrived at the functions. That one paragraph has inspired hundreds of papers by mathematicians, who have pondered its hidden meaning for eight decades.
"So much of what Ramanujan offers comes from mysterious words and strange formulas that seem to defy mathematical sense," Ono says. "Although we had a definition from 2002 for Ramanujan's functions, it was still unclear how it related to Ramanujan's awkward and imprecise definition."
Ono and his students finally saw the meaning behind the puzzling paragraph, and a way to link it to the modern definition. "We developed a theorem that shows that the bizarre methodology he used to construct his examples is correct," Ono says. "For the first time, we can prove that the exotic functions that Ramanujan conjured in his death-bed letter behave exactly as he said they would, in every case."
Although Ramanujan received little formal training in math, and died at the age of 32, he made major contributions to number theory and many other areas of math.
In the fall, Ono traveled to Ramanujan's birth home in Madras, and to other significant sites in the Indian mathematician's life, to participate in a docu-drama. Ono acted as a math consultant, and also has a speaking part in the film about Ramanujan, directed by Nandan Kudhyadi and set to premiere next year.
"I got to hold some of Ramanujan's original notebooks, and it felt like I was talking to him," Ono says. "The pages were yellow and falling apart, but they are filled with formulas and class invariants, amazing visions that are hard to describe, and no indication of how he came up with them."
Ono will spend much of December in India, taking overnight trains to Mysore, Bangalore, Chennai and New Dehli, as part of a group of distinguished mathematicians giving talks about Ramanujan in the lead-up to the anniversary date.
"Ramanujan is a hero in India so it's kind of like a math rock tour," Ono says, adding, "I'm his biggest fan. My professional life is inescapably intertwined with Ramanujan. Many of the mathematical objects that I think about so profoundly were anticipated by him. I'm so glad that he existed."
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The above story is reprinted from materials provided by Emory University. The original article was written by Carol Clark.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/0mLTtGAZgfg/121217091604.htm
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RAMALLAH, West Bank (AP) ? The Palestinian premier called on his people Sunday to boycott Israeli products, the latest step in an economic battle between Palestinians and Israelis spurred by the Palestinians' status upgrade last month at the United Nations.
Palestinian Prime Minister Salaam Fayyad, a U.S.-educated economist, told reporters the call for a boycott is a protest against Israel's withholding of funds to the cash-strapped Palestinian Authority.
Israel is holding $100 million in taxes it collects on behalf of the Palestinians, based on an interim peace accord. It cut off the funds to protest the Palestinians' successful bid last month at the United Nations, which granted the Palestinians non-state observer status. Israel said the Palestinian move was an attempt to bypass peace negotiations. Palestinians deny that.
Israel has briefly withheld tax transfers on previous occasions to pressure the Palestinians.
The Palestinian Authority government in the West Bank uses the money to pay salaries to its tens of thousands of civil servants and security forces. Israel said it is using the money to pay down huge debts Fayyad's government owes to Israeli firms, including its electricity company.
Fayyad admitted a Palestinian boycott of Israeli goods would violate an interim peace agreement with Israel, in which the two sides pledged economic cooperation, but he justified the move because "the Israeli government is working against this agreement" by withholding tax funds.
Israeli Foreign Ministry spokesman Yigal Palmor said the Palestinians should "concentrate efforts on how to build their own economy, not how to boycott someone else's."
In the past, Fayyad called for a boycott of goods made in Israeli settlements, but that boycott appears to have had no impact. Palestinians oppose settlements because they are located on West Bank land they claim for a future state.
This is the first time Fayyad has called for a boycott of all Israeli goods, not just ones made in West Bank settlements. Such a boycott would severely limit goods on the Palestinian market, as Palestinians are heavily dependent on Israel for consumer products.
To recoup its losses from the Israeli fund cutoff, the Palestinians have turned to Arab countries to donate funds.
"We are trying to prevent the collapse of the Palestinian Authority," Fayyad said.
Source: http://news.yahoo.com/palestinian-premier-boycott-israeli-goods-170151942--finance.html
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ROME (Reuters) - Italy's political parties began maneuvering on Sunday ahead of elections expected in February as supporters of technocrat Prime Minister Mario Monti sought to cajole him to stay in politics.
Monti has repeatedly said he would not campaign for power, but that he would be willing to serve again as an apolitical premier should the vote result be unclear.
But the premier's unexpected resignation in the face of People of Freedom (PDL) leader Silvio Berlusconi's attacks against his stewardship of the economy are fuelling speculation that Monti is ready to join the race.
Italian "progressives" from the centre-left's Democratic Party (PD) to the Union of the Centre (UDC) "identify with the reasonable and responsible policies Monti has made," UDC leader Pier Ferdinando Casini said on Sunday.
"A large part of civil society does not want to return to the populism and demagoguery of the past. We must give them the political offering they seek."
PD front-runner candidate Pier Luigi Bersani lauded Monti's plan to resign immediately after the passage of the budget, saying it showed great dignity. Bersani won a U.S.-style primary vote last week in which he promised to continue down the path taken by the premier.
The PD leads the PDL by at least 16 percentage points, according to polls from last week.
Berlusconi's campaign against European Union-inspired austerity that was put in place to stem the spread of a debt crisis "risks undermining the painful sacrifices that each Italian has made this year to save the national economy," PD lower house president Dario Franceschini said.
Italians are indeed burdened by the recession, which began mid-way through last year and shows no signs of abating. Many blame Monti's tax increases for making it worse. Unemployment is at a record high and consumer spending has collapsed.
"Eggs and potatoes, eggs and potatoes, that's all we can afford to eat right now," said Roberta Uzzo, who lives near the ancient walls of Rome. "It's a very ugly period. My husband is unable to find any work and with one sole income it's very difficult to go forward."
PDL secretary Angelino Alfano, whose attacks in parliament on Friday Monti said prompted him to step down, defended his party's decision to withdraw its support for the government.
"We think we did the right thing" in declaring Monti's government over on Thursday, Alfano said, "to underscore the struggles that Italians are facing because of the dire economic situation."
The consummate showman Berlusconi bashed Monti's leadership as he declared his sixth bid for power on the soccer pitch of his AC Milan team on Saturday, but Monti stole the scene by resigning later in the day and counter-attacking that "populism" was only a shortcut to winning votes.
MARKETS
Early elections in Italy must not hinder Monti's economic reforms, European Commission President Jose Manuel Barroso warned in an interview with financial daily Il Sole 24 Ore.
"The next elections must not serve as a pretext for putting in doubt how indispensable these measures are," he said in Sunday's edition. "The relative calm on the markets does not mean we are out of the crisis."
Berlusconi's withdrawal of support for the government last week triggered a new rise in 10-year bond yields, the main barometer of market opinion, reversing weeks of steady falls.
The yield on the 10-year BTP stood at 4.5 percent at the end of last week, 323 basis points higher than the yield on lower risk German 10-year Bunds, but much lower than the level of 7.3 percent seen last year.
Much will depend on how investors view the prospect of a potentially messy election campaign and a likely government of the centre-left, led by a former communist.
"From the perspective of international investors, it is worth noting that so far, I have heard nothing from the Bersani camp that would make me worry about Italian reforms or Italy's newly reclaimed place at the table among other leading European or G-7 members," Unicredit global chief economist Erik Nielsen wrote in a note.
Former European Commissioner Monti came to power at the height of the financial crisis a year ago and was widely credited with restoring Italy's credibility with investors and European partners after the scandal-plagued Berlusconi era.
"Whoever governs Italy, a founding member of the EU, is going to have to pursue this course with the same seriousness," European Central Bank executive board member Joerg Asmussen said on Sunday in Germany's Bild newspaper.
Berlusconi's centre-right PDL lags the PD by as much as 20 percentage points in opinion polls, and also trails the anti-establishment 5-Star Movement, which has surged to prominence on a tide of public anger against the mainstream political class.
Italy's four small centrist blocs would draw less than 10 percent of the vote if elections were held today, polls show.
(Additional reporting by James Mackenzie and Hanna; Rantala in Rome and Lisa Jucca in Milan; Editing by Barry Moody and Stephen Powell)
Source: http://news.yahoo.com/italian-parties-begin-campaigning-cajole-monti-153437304--business.html
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WASHINGTON, D.C. ? In Kansas State?s first true road game of the season at George Washington, the Wildcats clanked early and often in the first half, ended shooting less than 36 percent for the game. Fortunately, they also grabbed 24 offensive rebounds and combined with Angel Rodriquez?s second half scoring fueled a 65-62 victory.
"I?ll tell you one thing," K-State coach Bruce Weber said after the Wildcats improved to 7-1. "I?d love to make some shots so we haven?t so many offensive (rebounding) opportunities. Hopefully, that will come as it goes, but we got to continue to use that as a strength."
Another strength for the Wildcats was Rodriquez?s consistent second-half penetration. Following a dismal start ? he missed seven of eight field goal attempts ? the sophomore guard scored 14 of his 17 points in the second half, including five inside the final 1:46.
Playing in front of around 60 friends and family, D.C. native Rodney McGruder finished with 15 points and 11 rebounds.
K-State also played inside a raucous Smith Center as the Colonials (4-5) hosted their first BCS program since the 2009-10 season. Last season the Wildcats hosted and defeated George Washington 69-56. The Colonials play in the Atlantic 10.
After the Wildcats trailed by as many as seven before halftime, they led 44-37 following a 15-4 run early in the second half. The Colonials bounded back with a 13-4 run, going ahead 50-48 on Dwayne Smith?s 3-point play with 9:03 remaining, setting up the back-and-forth finish.
"As a coach you know that you?re walking into a tough environment," Weber said. "I?m not sure the kids understood it. To our guys credit, they hung in there we survived the first half, had a great run to start the second half and then even survived another run by then."
They survived shooting 31.6 percent in the first half by working the offensive glass; K-State?s first three baskets of the game all came on putbacks by Nino Williams.
McGruder scored 12 before halftime.
"It?s just great, having the opportunity to play in front of a lot family and friends and to do right in the heart of Washington, D.C.," McGruder said. "I couldn?t ask for a better opportunity."
For the game, the Wildcats finished at 35.7 percent (25 of 70), but held a 46-36 rebounding advantage with Thomas Gipson grabbing 12.
Isaiah Armwood had 12 points, 10 rebounds and a havoc-causing seven blocks for the Colonials while Smith had 14 points.
"I thought our defense was terrific," George Washington coach Mike Lonergan said. "If you told me we?re going to hold them to 35 percent shooting I thought we could win the game. But the killer was the 24 offensive rebounds."
Rodriquez?s second half prowess also destroyed the Colonials.
Williams? putback with 3:18 remaining put the Wildcats ahead for good. On their next possession ? which included another offensive rebound ? Rodriguez generated points by shrewdly taking advantage of his previous driving forays. With K-State leading 58-57, he wound up being fouled while attempting a 3-pointer then knocked down all three free throws with 1:46 left.
"Shot clock was going down and I felt like (the defender) was expecting me to drive cause I was driving constantly," Rodriquez said. "I was fortunate to get to the free throw line and make my free throws."
After Armwood made 3 of 4 free throws, Rodriguez sought out another driving opportunity. With his defender assuming the same, Rodriquez pulled up for a right-wing jumper with 1:03 left that pushed the lead back to 63-60.
"Angel made some huge plays when we needed it," Weber said
Source: http://www.kansas.com/2012/12/08/2596865/k-state-holds-off-george-washington.html
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Home | Apple Stock | Tracked Sites | TechNN | | E-Mail | Sherlock Plugin Close Left Panel | Login | Subscribe to MacSurfer's Headline News Poll | Most Popular | Talking Heads | A Year Ago Today | Checked 2:15 PM; Last Updated 1:55 PM CST; 19:55 GMT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Last Day! The MacLegion Holiday Bundle 2012 is now available. "We're offering you 11 best selling Mac apps valued at over $540.00 for a one-time-only exclusive price of?$49.99! That's over 90% off!" The bundle includes apps such as Alarm Clock Pro, TechTool Pro, Freeway Pro, RipIt, iRip, Beamer, and CopyPastePro, to name a few... How did Tim Cook do in his interview with NBC's Brian Williams? Cast your vote in "Today's Poll..." in the left column below or go straight to the results here. FRIDAY BLOWOUT: Every NEW or RENEWING paid subscriber receives 2 YEARS FREE.... Friday Highlights: NBC posts the full interview with Tim Cook; transcripts available at the Los Angeles Times, 9 to 5 Mac; Cook says the television is of intense interest to the company, tells Brian Williams no one should bet against Apple, Forbes' Anthony Kosner suggests though, that Cook mutes the real issues, while fellow Forbes writer Connie Guglielmo has ten follow up questions for Cook; the Associated Press says Apple's "softer side" is emerging; from the Albany Times Union comes word of top-secret talks that Apple, chip suppliers are looking to area for chip factory; WSJ on Apple's power within; MacStories maps out Apple's retail expansion; Judge Koh says Apple/Samsung spat feels like she's in Groundhog Day; Jonny Evans doesn't see a realistic scenario where the two companies will have patent peace; Horace Dediu on "the real threat" posed to Apple by Samsung; there is a hint in Microsoft's Hotmail-to-outlook.com push that a Mac client is in the works; whether Tim Cook's USA manufacturing comments are symbolic or not, hope is that other companies will step up and make it happen; Chuck Jones at Forbes analyzes Chitika's November report comparing iPad ad impressions against unit market share; Pepsi promo launched, to use Passbook; where do Apple's glass projects go from here?; if you were hoping your new 27" iMac would be under your Christmas tree, unfortunately you'll have to wait until January; the 21.5" model reviewed at Macworld, and Ars Technica which says the new box has taken two steps forward, but one back; PC Advisor reviews the 13" MacBook Pro; do you find reading text a little difficult on your iPad mini?; CNET's Maggie Reardon on whether malware should factor into the iPhone vs. Android debate; and Macworld's Chris Breen and Melissa Perenson debate iPad mini versus the Nexus 7. The MacUpdate December 2012 Bundle is now available. 12 apps for just $49.99. A $609 value at 92% off!" The bundle includes Mac apps such as Data Rescue 3, Live Interior 3D Pro, Snapz Pro 2.5, MacDVD Ripper Pro 4, PopChar X6, and Swift Publisher 3, to name a few... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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ROSWELL, N.M. (AP) ? New Mexico authorities say they're puzzled by what turned up in a package of meat at a Roswell grocery store.
A worker at Albertsons opened a case of frozen ribs Wednesday and found a handgun and ammunition packed with the meat.
Roswell police Sgt. Jim Preston tells Albuquerque television station KRQE (http://bit.ly/XwlNQB ) that it would be speculation to say how it got there.
Authorities have some clues.
A police report shows that the meat came from the Swift Packing Plant in Greeley, Colo., and is marked with the date June 8, 2011.
Greeley police say they're reviewing cases to see if the gun was used in any crimes.
Authorities say the semi-automatic Rock Island Armory .38 Super had not been reported stolen. A firearms trace could take weeks.
___
Information from: KRQE-TV, http://www.krqe.com
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In an exclusive interview with TOI, Pere Miro, director of NOC relations at the IOC, says that the body was forced to take such a decision after repeated warnings to set the house in order fell on deaf ears. Excerpts:
IOA has gone ahead and held elections. Apart from not recognizing the new committee, can the IOC penalize the IOA further?
The IOC does not recognize any such election and that is the end of the matter. As far as the IOC is concerned, Mr VK Malhotra was the functional president when the IOA was suspended and Mr Randhir Singh was the general secretary. We continue to recognize that and any further changes in the IOA don't really affect us.
Now that the IOA has been suspended, what is the stand vis-a-vis India's representative to IOC, Randhir Singh?
I'd like to make it clear that the action is against the IOA and not individuals. Mr Randhir Singh continues to hold his posts in the Olympic Association Of Asia and the IOC.
Has the Indian govt or the IOA approached the IOC after the suspension?
Since the suspension, nobody from India has approached us. We are open to dialogue. If anyone from India does approach us, we are ready to hold talks to sort out the issue. The IOC is keen to ensure that sporting activities happen in India smoothly.
What happens to Indian athletes participating in international events?
India cannot participate in any event held under the IOC jurisdiction as a nation as long as the suspension remains in force. That would include events like the Olympics and the Asian Games. When it comes to athletes, the issue will be dealt with on a case-by-case basis. However, in single sport, for example Asian Table Tennis Championship which is conducted by the ITTF, the IOC will respect the decision of the governing body of that sport.
What happens to the Olympic quota places up for grabs in these events?
Quota places for future games are an issue for us. The Olympic Games is still far away and we do hope the issue with the IOA is resolved by then. As of now, if any Indian earns a quota place, the IOC won't really take any decision on that. However, if the issue is not resolved by the time of the Olympics, the IOC would have to take some decision. As of now, the IOC will just wait.
The Indian govt says it only wants to ensure fair elections at IOA in accordance to the Olympic Charter. Your reactions.
If the Indian government says it is not interfering with the IOA election, we would welcome the idea and we would want to understand the details. If they say that they are following the Olympic Charter, they should show it. The Olympic Charter ensures harmony among the IOC, the 204 National Olympic Committees and the laws of all the countries. Normally, we would deal with the IOA only. But then, in this case, we are open to discussions with the Indian government. We are waiting to have dialogue with anyone interested in doing so.
The Indian judiciary wanted IOA elections as per the Sports Code. How could the IOA defy the Court?
We respect the decisions of justice in every nation. But then, the judges will deliver their verdict as per the laws of the nation. The concerned nation should look at the laws regarding sport and ensure that the sports organizations remain autonomous and in harmony with the principles of the Olympic Charter.
Source: http://timesofindia.feedsportal.com/fy/8at2Etd0ha35N3fE/story01.htm
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If funding is successful, you'll be able to wave hello to Edison Junior's DoorBot -- an app-enabled, WiFi-connected video doorbell. Sure, it's not exactly the first time we've seen such an idea, but the "weather-resistant," aluminium enclosure makes it one of the best looking concepts we've seen. Better yet, the system is set to work in unison with the Lockitron (a smartphone-controlled keyless door lock that was recently crowd-funded, albeit still yet to ship) allowing you to let welcome visitors inside your abode at the tap of your iOS or Android Device's app screen.
The DoorBot installs with four screws, but it'll have you running through four AA batteries once a year for power (which, based on the video, seem easily removeable by strangers, unfortunately). There's no word on the quality of the camera onboard, however, it's infared-equipped, so you'll be able to see who's there at night. Lastly, the actual doorbell button is wrapped with an LED light, and, as you'd expect, it alerts you via the app when pressed to see and speak with whomever is at the door.
In total, Edison Junior hopes to raise a lofty $250,000 to make the DoorBot more than a concept video, with 45 days to reach the goal. If you're willing to take the gamble as backer, $169 is what'll cost to secure a pre-order, and $319 snags you one bundled with the Lockitron. We're told that we'll see a working prototype in the flesh at CES, but until then, you can catch the full sales pitch at the source link and video demo after the break.
Filed under: Household
Source: Edison Junior (Christie Street)
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Z7xrhvDuxZ8/
ScienceDaily (Dec. 6, 2012) ? For much of her professional life, Dr. Susan Rosenberg has studied the puzzling response of bacteria to stress and the mutations that result. In the current issue of the journal Science, she puts together the pieces of that puzzle, describing most of the members of an elaborate gene network that functions in causing mutations during repair of double-stranded breaks in the DNA of stressed cells.
"We now know the 93 genes more than half of which are funneling into three nodes that go down the mutagenesis pathway," said Rosenberg, professor of molecular and human genetics at Baylor College of Medicine and 2009 winner of the National Institutes of Health Director's Pioneer Award.
Groundbreaking work
Rosenberg's groundbreaking work has shown that the rate of mutation can be increased in response to stress such as starvation or environmental challenges such as antibiotics. This changes old ideas about constant and gradual accumulation of mutations over time. Some mutations are detrimental; others can promote survival. In this work, she and her colleagues sought to define the cellular pathways that result in this stress response.
"We screened for every gene in Escherichia coli that is needed to make this happen," said Rosenberg. E. coli is a "model" organism often used in the laboratory to study cells, because its DNA and other components work similarly to those in humans.
They have found that the mutagenic part of the process is not required to repair the broken DNA strands. When they "knock out" or remove the special "error-prone" DNA copying enzyme or polymerase, "the DNA is repaired beautifully and there are no mutations." So, cells do not make mutations because they have to, to repair DNA. Rather, this mechanism appears to regulate production of mutations, making more during stress, when cells are poorly adapted to their environments, and most likely to benefit from mutations.
Painstaking process
"Fewer than 16 proteins that are needed to accomplish stress-inducible mutagenesis were known previously. This is about the number known for any molecular mechanism of DNA biology," said Rosenberg. "Our screen sought the whole list of all proteins the cell uses to make it happen."
The painstaking process, begun by then postdoctoral fellow Dr. Mary-Jane Lombardo, now of Seres Health, Inc., in Cambridge, Mass., was completed by Dr. Amar Al Mamun, an assistant professor in Rosenberg's laboratory at BCM.
Large fractions of the network work "upstream" of the activation of the stress response, showing that these proteins apparently "sense" the stress. In delineating how the network functions, Rosenberg and her colleagues identified specific pathways through which the proteins sense the environment and connected them to the molecular mechanism that promotes the mutations.
Key factors revealed
The findings reveal key factors about the cells, such as that stress-response regulators act as key network hubs, she said. Most of the proteins in the network deal with whether or not the cells feel stress, said Rosenberg.
"The cell devotes a large number of proteins to controlling the process that generates diversity," she said. "And most of them are sensing the environment and coupling mutagenesis to stress."
They have determined the function of about half the network and are working on the rest.
"It's a resounding confirmation of the regulation of mutagenesis by stress responses, which causes mutations specifically when cells are maladapted to their environment when mutations might allow the cell to adapt," said Rosenberg.
Protein networks
It is also a demonstration that one can hope to detangle large protein networks into specific biological functions. Large protein networks are being discovered in many areas of biology, but what roles the proteins play in particular biological processes is often difficult to determine. Rosenberg's study shows that by working backwards from a defined molecular mechanism, they could assign roles to more than half the network proteins. Rosenberg thinks this strategy will be useful for many other protein networks.
Funding for this work came from grants from the National Institutes of Health and National Science Foundation.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/fK3OEfGMG4g/121206142014.htm
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Dreams can come true, folks: T-Mobile and Apple have entered an agreement and will be launching products beginning next year. The announcement was posted (nearly as an afterthought, oddly enough) as part of a press release in which Deutsche Telekom spelled out its financial plans through 2015, while COO Rene Obermann also made the announcement in an investors conference. While the two companies have not explicitly given specifics on which Apple devices we can expect to see in a retail store near you, the timing of the launch will likely correspond with the fourth-largest carrier's LTE launch in 2013.
We've reached out to T-Mobile and Apple for comment and will update this post as we hear more. For now, check out the press release in all its glory below.
Developing..
Continue reading T-Mobile and Apple sign agreement to launch products in 2013
Source: Deutsche Telekom (Twitter), Deutsche Telekom
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ywonCmcd6EQ/
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